9-year-old Sheldon Cooper is a once-in-a-generation mind capable of advanced mathematics and science but learns that isn’t always helpful growing up in East Texas, a land where church and football are king.
When Mary takes a job as church secretary, she finds herself becoming Pastor Jeff's marriage counselor. Also, Sheldon and Missy spend their first afternoon home alone.
Sheldon makes friends with an upperclassman who introduces him to a new field of science. Also, Mary and George disagree on how to handle Sheldon's blossoming social life.
When Dr. Sturgis bonds with Paige, another 10-year-old genius, Sheldon’s jealousy leads Meemaw to intervene. Mary invites Paige’s family over for a play date.
Mary clashes with Sheldon's drama teacher over plans for a Halloween fundraiser for the church; Georgie falls for a rebellious teenage girl whom Sheldon is tutoring.
When Sheldon learns that people with stunted childhoods can turn into social outcasts, he tries to act like a kid. Also, Meemaw and Dr. Sturgis' (Wallace Shawn) relationship is tested when she teaches him how to drive.
When Sheldon has to spend a few days in the hospital, he turns into the world’s worst patient. Also, Missy gets a taste of what life would be like without her twin.
Sheldon attempts to build a nuclear reactor. Also, a university cocktail party gets heated when Dr. Sturgis’ colleague, Dr. Linkletter, flirts with Meemaw, and Georgie is heartbroken when he learns Veronica has a boyfriend.
Sheldon and Dr. Sturgis have their first fight when Dr. Sturgis marks a question wrong on Sheldon's test. Also, Mary takes over for Pastor Jeff when he's out sick.
Things spiral out of control when Sheldon boycotts his favorite bread company. Also, Georgie offers Veronica a shoulder to cry on when she's dumped by her boyfriend.
Sheldon moves in with Dr. Sturgis for the weekend to see what his life will be like in college. Also, a lonely Mary tries to bond with the other Coopers during Sheldon's absence.
The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.
Sheldon invites the entire school to a party for the Nobel Prize announcements. Also, Meemaw learns more about Dr. Sturgis' past, and Georgie's desire for cable TV leads to a standoff between him and George Sr.
After Dr. Sturgis experiences a nervous breakdown, Mary worries Sheldon is headed down a similar path. Also, Georgie discovers he has a knack for sales.
Without Dr. Sturgis’ university class, Sheldon must find a new way to stay academically challenged. Also, Mary helps Pastor Jeff avoid temptation with his girlfriend.
Sheldon takes matters into his own hands when Meemaw refuses to drive him to a lecture with Dr. Linkletter. Also, Georgie tries to impress Veronica with his new business venture
Sheldon is forced to take a break from science when his new obsession with “The Lord of the Rings” leads to an unhealthy habit. Also, Missy asks George Sr. to teach her how to play catch.
Sheldon starts an internet flame war, and Missy stands up to the boys on her baseball team. Also, Meemaw is unhappy when George Sr. spends time with her new boyfriend.
The University makes George Sr. a lucrative job offer in the hopes of recruiting Sheldon. Also, Georgie gets a job working for Meemaw's new boyfriend, and Mary is determined to rid her home of greed.
George Sr. and Georgie go camping with Meemaw's new boyfriend, Dale, but things get complicated when her ex-boyfriend, Dr. Sturgis, tags along. Also, Sheldon and Missy invent a super-game.
Sheldon visits CalTech for the very first time. Also, Georgie is furious when Mary listens in on a phone call with his girlfriend, and Meemaw tries to cheer up a jealous Missy.
When Sheldon learns the house next door is for sale, he takes it upon himself to find the perfect neighbors. Missy is torn when she’s forced to pitch against her boyfriend at the baseball game.
Sheldon has a scientific breakthrough at the dentist's office. Also, Dale (Craig T. Nelson) and Meemaw go to the casino, and Georgie makes a big mistake when Dale leaves him in charge of the store
Sheldon gets a summer job at the local train museum. Also, George and Missy bond when Missy embarks on a new stage of womanhood, and Georgie discovers Mary's guilty pleasure.
Dale and Meemaw work out relationship issues while playing Dungeons and Dragons with Sheldon and Missy. Also, Mary and George take a trip with Coach Wilkins and his wife, and Georgie freaks out when his girlfriend thinks she's pregnant.
College orientation does not go as Sheldon planned. Also, Mary is invited to a party when she's mistaken for a university student, and George Sr. helps Pastor Jeff set up a children's nursery.
Sheldon's first day of college is derailed by his new philosophy teacher, Professor Ericson. Also, Mary and Brenda live vicariously through Missy's first day of middle school.
Meemaw takes matters into her own hands when Sheldon's philosophy teacher, Professor Ericson, sends him into a tailspin. Also, George Sr. learns Georgie has been cutting class.
Sheldon and George Sr. dine with President Hagemeyer and a university benefactor. Also, Georgie gives Missy some brotherly advice when Mary won't let her go to the school dance, and Dale and June convince Meemaw to attend their son's wedding.
Sheldon campaigns to become Dr. Linkletter's lab assistant. Also, Georgie enlists the help of Mr. Lundy, the drama teacher, for a surprising business venture.
Sheldon, Dr. Linkletter and Meemaw team up on a science experiment. Also, Mary is jealous that Pastor Jeff and Brenda are spending time together, and Georgie has a new side hustle.
Sheldon refuses to ride in a car after getting into an accident with Meemaw. Also, Missy uses their trauma to her advantage at school and Meemaw is forced to take the church shuttle while her car is in the shop.
When the IRS accuses Sheldon of making a mistake, he'll stop at nothing to prove them wrong. Also, Dale is forced to get a colonoscopy and tries to convince Meemaw to join him.
Sheldon is caught in a moral dilemma when offered a bootleg copy of a computer game he can't afford. Also, Mary and Meemaw take Brenda out for girls' night while George Sr. and the guys watch Billy, and Missy asks Georgie to take her and Marcus on a secret date.
Sheldon finds himself at odds with Paige once again when she considers enrolling at East Texas Tech. Also, Mary seeks June's advice when looking for a change.